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OSA Vet
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ATLAS
BROCHURE
BIBLIOGRAPHY

Interferometry

ICP OSA-VET DRY EYE ANALYSIS
OSA-Vet is an instrument available to veterinary ophthalmologists to evaluate the composition and stability of the Precorneal Tear Film (PTF). It allows to better evaluate PTF qualitative deficiencies and make an accurate diagnosis of evaporative Dry Eye Disease (DED) due to imbalance of the three main PTF components:
  • Lipids
  • Aqueous
  • Mucins
Thanks to OSA-Vet it is possible to identify the type of DED, determine which deficient layer is affected and select a specific treatment.
TEAR FILM LIPID LAYER EXAMINATION
The scattered light emitted by the OSA-Vet system allows to evaluate the interference patterns coming from the Lipid Layer (LL) of the tear film.
The different patterns can be classified according to LL thickness and quality.
OSA-VET ALLOWS TO QUANTIFY DIRECTLY AND INDIRECTLY EACH SINGLE TEAR FILM LAYER
The white LED allows to show the phenomenon of interference fringes, that depends on the different thicknesses of the lipid layer of the tear film.
IMMEDIATE INTERPRETATION AND FOLLOW UP
By using a dedicated lipid layer grading scale, each interference pattern may be examined in a simple and straightforward way.
SUPPLIED ACCESSORIES
The system is provided with a kit of useful grids to perform various screenings. All filters are already present in the OSA-Vet package.
  • A thick grid to observe the quality of the tear film
  • A fine grid to evaluate the quality and the structure of tear film and measure the N.I.B.U.T.
  • A Placido disc to highlight possible distortions or corneal and tear film irregularities.

Tear meniscus

TEAR MENISCUS
The thickness of the tear meniscus that is observed on the eyelid margins provides useful information on the tear volume. The tear meniscus can be examined considering its height, regularity and shape.
PRE-CORNEAL TEAR FILM THICKNESS AND TEAR MENISCUS HEIGHT
In dogs and cats, the Pre-corneal Tear Film (PTF) is about 8 µm thick on the central cornea, but it is much thicker at the meniscus.
By examining the meniscus, it is possible to evaluate the lacrimal glands aqueous production.

Nibut

NIBUT
The OSA-VET allows to study the tear film Non Invasive Break Up Time (N.I.B.U.T.).
The Break Up Time (B.U.T.) test studies the tear film break up time with the use of fluorescein dye on the cornea. This test can cause reflex tearing and change tear film properties.
On the contrary, the N.I.B.U.T. test is carried out without the use of fluorescein and is harmless and well tolerated in animals
In animals, the eye and third eyelid movements and lack of coopereation due to the animal's head restraint may interfere with both B.U.T. exams.
PLACIDO DISC
To evaluate corneal topography and tear film defects by the projection of Placido rings on ocular surface.

Meibography

OSA-VET MEIBOGRAPHY
Meibography allows to evaluate the morphology and drop out of the meibomian glands and to make the diagnosis of Meibomian Gland Dysfunction (MGD).
The software allows to analyze the functional and non functional areas, and to evaluate the extension of the affected area.
A convenient hand held device with two infrared filters and a built in camera. The OSA-Vet system captures and displays images of the meibomian glands straight on your computer.
Features:
  • Seamless and wireless capturing of images for added convenience
  • Image capture button freezes live images which are instantly displayed on the computer
  • Captured image enhancement tools: contrast, brightness and hue
  • settings to improve and highlight captured images
  • Define area for analysis and visible area of glands. Calculations of gland loss is then displayed graphically
  • Progression analysis provides a split screen for side by side image comparisons over time.
MG ANALYSIS
Our device easily and efficiently integrates complex examinations such as meibography and tear film interferometry screening. The I.C.P. allows to:
  • Calculate the percentage of functional glands in a selected area
  • Point out through a change of colour the areas with and without glands
  • Classify in 4 different degrees the loss of meibomian glands
    A. Loss between 0 and 25 %: green
    B. Loss between 25 and 50%: yellow
    C. Loss between 50 and 75 %: orange
    D. Loss between 75 and 100%: red
  • Change the brightness of the images for a better evaluation.
AUTOMATIC DETECTION OF MEIBOMIAN GLANDS IN SELECTED AREAS
The I.C.P. (Integrated Clinical Platform) allows to record good quality images and to study the length and width of meibomian glands.
The images are automatically classified.
The position of the meibomiam glands in the eyelids is automatically detected.

Other examinations

WHITE TO WHITE MEASUREMENT
Evaluation of corneal diameter from limbus to limbus (white-to-white distance, WTW).
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Atlas

Veterinary Bibliography

1. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 1. The normal tear film in the dog. The Journal of Small Animal practice, 1987, 28, 605-622
2. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 2. Keratoconjunctivitis sicca in the dog. The Journal of Small Animal practice, 1987, 28, 671-679
3. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 3. The normal tear film in the cat. The Journal of Small Animal practice, 1987, 28, 821-826
4. Davidson HJ, Kuonen VJ. The tear film and ocular mucins, Veterinary Ophthalmology, 2004, 7, 2, 71-77
5. Cullen CL et al. Tear film breakup times in young healthy cats before and after anesthesia. Veterinary Ophthalmology 2005, 8,3, 159-165
6. Featherstone HJ,  Heinrich CL. Ophthalmic examination and diagnostics. In Veterinary Ophthalmology, edited by KN Gelatt, BC Gilger, TJ Kern, fifth edition, vol. 1, 2013, 533-613. Wiley-Blackwell, Ames, Iowa, USA
7. Geerling G et al. The International workshop on Meibomian  gland dysfunction: report of the subcommittee on management and treatment of MGD. Investigative Ophthalmology & Visual Science, 2011, 52, 2050-2064
8. Hodges RH, Dartt DA. Tear film mucins: front line defender of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res, 2013,117, 62-78
9. Inatomi T, Spurr-Michaud S, Tisdale AS, Gipson IK. Human corneal and conjunctival epithelia express MUC1 mucin. Investigative Ophthalmology and Visual Science 1995; 36: 1818-1827
10. Knop E et al. The International workshop of Meibomian gland dysfunction: report of the subcommittee on anatomy,physiology and pathophysiology of the Meibomian gland. IOVS 2011, 52,4,1938-1978
11. Lemp MA et al. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007, 5(2):75-92
12. Lozato PA et al. The lipid layer of the lacrimal tear film: physiology and pathology. J Fr Ophthalmol, 2001, 24, 6, 643-658
13. Maggio F, Pizzirani S. Patologie del film lacrimale e delle superfici oculari nel cane e nel gatto. Parte 1. Cenni di fisiopatologia
14. Maggio F,  Pizzirani S. Patologie del film lacrimale e delle superfici oculari nel cane e nel gatto. Parte 2. Segni clinici, diagnosi e terapia. Veterinaria, 2009, 23, 5, 55-70
15. Maggs DJ, Miller PE, Ofri R. Slatter's Fundamentals of Veterinary Ophthalmology. Fifth edition, 2013, Elsevier St Louis
16. Miller PE.  Lacrimal System in Slatter's Fundamentals of Veterinary Ophthalmology. 2013 Editors DJ Maggs, PE Miller, R Ofri.  Elsevier St Louis
17. Nichols KK et al. The International workshop on Meibomian  gland dysfunction: executive summary. Investigative Ophthalmology & Visual Science, 2011, 52, 1922-1929
18. Saito A, Kotani T. Estimation of lacrimal level and testing methods on normal beagles. Veterinary Ophthalmology 2001, 4, 1,7-11
19. Sebbag L  et al. Reference values, interest correlations, and test -retest repeatability of selected tear film tests in healthy cats. J Am Vet Med Assoc. 2015, 15, 246 (4), 426-435
20. Sebbag L et al. Goblett cell density and distribution in cats with clinically and histologically normal conjunctiva. Veterinary Ophthalmology 2016, 19, suppl. 1, 38-43
21. Wang J et al. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids.  Investigative Ophthalmology Visual Sciences October 2006, 47, 10,  4349-4355
22. Yokoi N et al. Reflective meniscometry: a new field of dry eye assessment. Cornea, 2000 May;19 (3 Suppl): 37-43

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