System analysis of the images is obtained through a sensitive infrared camera (NIR) in order to locate in a guided way:
- The position detected from the image, valid both for the upper and lower eyelid
- Percentage of the loss area of meibomian glands, to know the presence/absence of them
- Grading scale to classify the status in 4 different degrees (0-25% green, 25-50% yellow, 50-75% orange, 75-100% red),
It serves to build the morphology, diagnosis and drop out of the meibomian glands. Meiboscopy is the visualization of the glands through illumination of the eyelid with infrared light.
The software allows to analyze the working and not working areas, and to compare the glands of the patient with the diagnostic evaluation scales.
The MGD alters lipid component of the tear film and this can cause the appearance of dry eye with its characteristic symptoms. In severe cases, the MGD can also cause inflammation of the eyelids called blepharitis rear edge.
ICP MGD can, with a good quality of image, in a guided way detect the length and width of meibomian glands imaged by infrared meibography without requiring any input from the user.
The images are then automatically classified.
The analysis of the glands happens in an automatic way thanks to the advanced recognition software that studies the eyelid through the use of dedicated filters in real time after the acquisition.
MGD is a chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion. It may result in alteration of the tear film, symptoms of eye irritation, clinically apparent inflammation, and ocular surface disease. In a few seconds the device allows to take photo with high resolution in infrared vision making visible in every environmental condition the presence/absence of the glands on the eyelids.
A dedicated web connected platform allows to process all collected data, generate graphics and release documents to be added to the animal's clinical folder.
For dry eye diagnosis are recommended a series of exams:
- Measurement of the blinking frequency and calculation of the inter blink interval
- Measurement of the height of the lower tear meniscus
- Measurement of the tear osmolarity (if available)
- Calculation of the tear film break up time (TFBUT) and the index of ocular protection (OPI)
- Classification of the corneal and conjunctival coloration with fluorescein
- Schirmer Test
- Phenol red test
- Quantification of the morphological characteristics of eyelids
- Squeezing: quantification of the squeezability and of the quality of the lipid component
- Meibography: quantification of atrophy.
MGD VET Brochure (English)
Bags, resistant material to large stresses, have the particularity to be watertight with IP 67 impermeability and the perfect seal for liquids and dust, this is ensured by a rubber seal along the entire closure profile; is also present in all models a balancing valve of the internal and external pressure.
1. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 1. The normal tear film in the dog. The Journal of Small Animal practice, 1987, 28, 605-622
2. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 2. Keratoconjunctivitis sicca in the dog. The Journal of Small Animal practice, 1987, 28, 671-679
3. Carrington SD et al. Polarized light biomicroscopic observations on the precorneal tear film: 3. The normal tear film in the cat. The Journal of Small Animal practice, 1987, 28, 821-826
4. Davidson HJ, Kuonen VJ. The tear film and ocular mucins, Veterinary Ophthalmology, 2004, 7, 2, 71-77
5. Cullen CL et al. Tear film breakup times in young healthy cats before and after anesthesia. Veterinary Ophthalmology 2005, 8,3, 159-165
6. Featherstone HJ, Heinrich CL. Ophthalmic examination and diagnostics. In Veterinary Ophthalmology, edited by KN Gelatt, BC Gilger, TJ Kern, fifth edition, vol. 1, 2013, 533-613. Wiley-Blackwell, Ames, Iowa, USA
7. Geerling G et al. The International workshop on Meibomian gland dysfunction: report of the subcommittee on management and treatment of MGD. Investigative Ophthalmology & Visual Science, 2011, 52, 2050-2064
8. Hodges RH, Dartt DA. Tear film mucins: front line defender of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res, 2013,117, 62-78
9. Inatomi T, Spurr-Michaud S, Tisdale AS, Gipson IK. Human corneal and conjunctival epithelia express MUC1 mucin. Investigative Ophthalmology and Visual Science 1995; 36: 1818-1827
10. Knop E et al. The International workshop of Meibomian gland dysfunction: report of the subcommittee on anatomy,physiology and pathophysiology of the Meibomian gland. IOVS 2011, 52,4,1938-1978
11. Lemp MA et al. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007, 5(2):75-92
12. Lozato PA et al. The lipid layer of the lacrimal tear film: physiology and pathology. J Fr Ophthalmol, 2001, 24, 6, 643-658
13. Maggio F, Pizzirani S. Patologie del film lacrimale e delle superfici oculari nel cane e nel gatto. Parte 1. Cenni di fisiopatologia
14. Maggio F, Pizzirani S. Patologie del film lacrimale e delle superfici oculari nel cane e nel gatto. Parte 2. Segni clinici, diagnosi e terapia. Veterinaria, 2009, 23, 5, 55-70
15. Maggs DJ, Miller PE, Ofri R. Slatter's Fundamentals of Veterinary Ophthalmology. Fifth edition, 2013, Elsevier St Louis
16. Miller PE. Lacrimal System in Slatter's Fundamentals of Veterinary Ophthalmology. 2013 Editors DJ Maggs, PE Miller, R Ofri. Elsevier St Louis
17. Nichols KK et al. The International workshop on Meibomian gland dysfunction: executive summary. Investigative Ophthalmology & Visual Science, 2011, 52, 1922-1929
18. Saito A, Kotani T. Estimation of lacrimal level and testing methods on normal beagles. Veterinary Ophthalmology 2001, 4, 1,7-11
19. Sebbag L et al. Reference values, interest correlations, and test -retest repeatability of selected tear film tests in healthy cats. J Am Vet Med Assoc. 2015, 15, 246 (4), 426-435
20. Sebbag L et al. Goblett cell density and distribution in cats with clinically and histologically normal conjunctiva. Veterinary Ophthalmology 2016, 19, suppl. 1, 38-43
21. Wang J et al. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Investigative Ophthalmology Visual Sciences October 2006, 47, 10, 4349-4355
22. Yokoi N et al. Reflective meniscometry: a new field of dry eye assessment. Cornea, 2000 May;19 (3 Suppl): 37-43